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Can I be on antidepressants for life?

It’s a common question many people have when starting antidepressant medication – can I take this indefinitely, or will I have to come off it at some point? The short answer is yes, it is often safe and recommended to stay on antidepressants long-term, as long as you are monitoring yourself for side effects and the medication continues working. There are some important factors to consider when making the decision to take antidepressants long-term.

Why long-term antidepressant use may be recommended

There are a few key reasons why your doctor may recommend staying on antidepressants indefinitely:

  • To prevent depressive episodes from returning – For many people, antidepressants help prevent recurring episodes of depression. Staying on them long-term reduces your risk of relapsing.
  • Your depression is chronic – If your depression is chronic or clinical in nature, meaning it is a long-term, serious medical condition, then your doctor will likely recommend staying on antidepressants long-term to manage it.
  • Other treatments haven’t worked – If you have tried psychotherapy, lifestyle changes, etc. and still struggle with depression, long-term medication may be your best solution for managing symptoms.
  • You’ve had multiple depressive episodes – The more episodes of depression you have had, the higher your risk of having another. Long-term antidepressants can help prevent relapses.
  • You have a family history – A family history of chronic or recurring depression means you are at higher genetic risk, and long-term medication can reduce that risk.

Your doctor will evaluate your specific case, history, and risk factors before recommending long-term antidepressant use.

What are the potential benefits?

There are many potential benefits to staying on antidepressants long-term:

  • Prevention of future depressive episodes – This is one of the major benefits. Antidepressants can reduce your risk of relapse by up to 70% or more for certain medications.
  • Avoiding withdrawal effects – Coming off antidepressants suddenly can cause unpleasant withdrawal symptoms. Staying on them prevents this.
  • Consistency in managing symptoms – Keeping your medication and dosage constant provides stability in managing your depression.
  • Not having to re-adjust – Restarting antidepressants means starting over with side effects and dosage adjustments.
  • Peace of mind – The reassurance of knowing your depression is under control can provide peace of mind.
  • Independence – Not having to rely on regular psychotherapy for depression management gives you independence.
  • Work productivity – Preventing recurring episodes helps you maintain work productivity.

For many people, the benefits of reduced relapses and consistent symptom management outweigh the downsides of being on medication long-term.

What factors should be considered?

There are also some important factors to consider before committing to lifelong antidepressant use:

  • Side effects – Side effects may be tolerable short-term but problematic long-term. Discuss your side effects.
  • Effectiveness over time – Antidepressants can lose effectiveness. Regular check-ins allow adjustment if needed.
  • Withdrawal symptoms – Stopping after long-term use can cause sometimes severe withdrawal effects.
  • Psychotherapy – Consider if psychotherapy could provide enough depression management over time.
  • Pregnancy – Most antidepressants have risks if taken while pregnant. This may affect plans for pregnancy.
  • Cost – The financial costs of medication and provider visits add up over years.
  • Lifestyle factors – Long-term medication means not addressing potential lifestyle contributors.
  • Comorbid conditions – Other conditions like anxiety may also need to be managed long-term.

Discussing the pros and cons of lifelong antidepressant use with your provider allows you to make an informed decision.

Are there any health risks or complications?

For most people, there are no major health risks associated with long-term antidepressant use. However, there are some potential issues to be aware of:

  • Loss of effectiveness – Your body can get used to medications over time, causing them to lose effectiveness. This may require adjusting dosage or switching medications.
  • Side effects – Side effects like weight gain, sexual dysfunction, digestive issues, etc. may get worse over time on certain medications.
  • Withdrawal symptoms – Stopping abruptly after years of use can trigger symptoms like dizziness, flu-like symptoms, insomnia, and anxiety.
  • Drug interactions – The more medications you take long-term, the higher the risk of negative drug interactions.
  • Pregnancy risks – Most antidepressants pose risks like birth defects if taken during pregnancy.
  • Relapse after stopping – Your depression may return worse than before if you stop medication after long-term use.

While not common, it’s important to monitor yourself closely and discuss any changes with your provider. Some side effects or drug interactions can become serious over time if not addressed.

How do I stop antidepressants after long-term use?

If you’ve taken antidepressants for years and want to stop, it’s extremely important to consult your doctor and taper off slowly and gradually to prevent withdrawal effects.

A general tapering schedule guideline is to lower your dose by about 25% every 4 weeks. However, an exact schedule depends on factors like:

  • The specific medication (some require slower tapering)
  • Your current dosage
  • How long you’ve been taking it
  • Your sensitivity to withdrawal effects

Work closely with your provider to create a customized tapering plan for you. Never attempt to stop suddenly or taper too quickly on your own. With careful tapering, withdrawal symptoms can be minimized or avoided.

What alternatives are there to lifelong medication?

Some alternatives to staying on antidepressants indefinitely include:

  • Psychotherapy – Ongoing counseling and cognitive-behavioral therapy (CBT) help some manage depression long-term without medication.
  • Mindfulness meditation – Research shows mindfulness practices can provide long-term depression relief.
  • Exercise – Regular exercise boosts mood naturally and is effective at preventing depressive episodes.
  • Light therapy – Daily use of a light therapy box has been shown to manage depression with minimal side effects.
  • Nutritional therapy – Improving your diet and ensuring adequate intake of nutrients like omega-3s, B-vitamins, etc. can alleviate symptoms.
  • Acupuncture – Some studies demonstrate acupuncture can provide lasting depression relief.

See if adding one or a combination of these options allows you to wean off or minimize antidepressant use under your doctor’s supervision.

When is lifelong medication likely necessary?

For some people with severe, chronic, or very recurrent forms of depression, medication may be necessary indefinitely. This is more likely if:

  • Your depression is very resistant to other treatments.
  • You have a history of multiple severe depressive episodes.
  • You have a family history of chronic depression.
  • You have bipolar disorder or another depressive illness.
  • Your depression has psychotic features.
  • Your depression is accompanied by anxiety or OCD.
  • You’ve been hospitalized for depression.

For severe cases like these, antidepressants are often critical to managing symptoms and maintaining stability long-term. Working closely with a psychiatrist can help find the most effective medication regimen.


Overall, lifelong antidepressant use is safe and often recommended for many people to prevent recurring depressive episodes. However, it does require careful consideration of the benefits and risks for your individual situation. Check in regularly with your provider about how well your medication is working and discuss any side effects. While not for everyone, long-term antidepressants can provide lasting relief if you suffer from chronic, severe, or recurrent depression.