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What drug do they give at end of life?

End-of-life care is a critical aspect of healthcare that focuses on providing comfort and support to individuals who are nearing the end of their lives. It involves various forms of care, including pain management and symptom relief. Medication plays a crucial role in alleviating discomfort and enhancing the quality of life for patients during this stage. In this blog post, we will explore the common drugs prescribed at the end of life and discuss the considerations for their selection and administration.

Common Drugs Prescribed at the End of Life


Acetaminophen, also known as paracetamol, is a commonly used drug for pain management. It can help relieve mild to moderate pain and is often recommended as a first-line treatment. Acetaminophen works by reducing the production of certain chemicals in the body that cause pain. It is typically administered orally, and the dosage may vary based on factors such as the patient’s weight and underlying medical conditions. Close monitoring of the patient’s liver function is essential, as high doses or prolonged use of acetaminophen can cause liver damage.


Haloperidol is an antipsychotic medication commonly used at the end of life to manage symptoms such as delirium and anxiety. Delirium is a state of confusion that can occur in seriously ill patients, and haloperidol can help reduce agitation and restlessness associated with this condition. This medication is usually administered orally or intravenously, and the dosage is determined based on the individual’s needs and response. It’s important to regularly assess the patient for any side effects or adverse reactions to ensure optimal care.


Lorazepam is a benzodiazepine drug that is often prescribed to manage anxiety and restlessness in patients at the end of life. It can help induce a sense of calm and promote relaxation. Lorazepam is available in various forms, including oral tablets and sublingual tablets that dissolve under the tongue. The dosage is tailored to the patient’s specific needs, taking into account factors such as their age, overall health, and any existing medical conditions. Careful monitoring of the patient’s respiratory status is crucial when administering lorazepam, as it can cause respiratory depression in high doses.


Morphine is a powerful opioid medication commonly used for pain relief in patients with advanced illnesses. It is effective in managing moderate to severe pain and can also provide respiratory comfort when needed. Morphine can be administered orally, transdermally (through a patch applied to the skin), or intravenously, depending on the patient’s condition and preferences. The dosage is carefully titrated to achieve optimal pain control while minimizing side effects such as sedation and respiratory depression. Regular assessment of the patient’s pain levels and response to the medication is crucial for ensuring adequate pain management.


Prochlorperazine is an antiemetic medication used to manage nausea and vomiting, which can be distressing symptoms for patients at the end of life. It works by blocking certain receptors in the brain that trigger nausea and vomiting. Prochlorperazine is usually administered orally, although other forms such as suppositories may be used in some cases. The dosage is adjusted based on the individual’s needs and tolerance, taking into consideration factors such as their age and overall health. Close monitoring for any adverse effects, such as sedation or movement disorders, is important with the use of prochlorperazine.


Atropine is a medication commonly found in emergency kits in hospice facilities. It is used for the drying of respiratory secretions, which can help patients who are experiencing excessive or distressing mucus production. Atropine is typically administered sublingually or rectally, but in emergency situations, it may also be given intravenously. The dosage varies depending on the patient’s specific needs and the severity of their symptoms. Careful monitoring of the patient’s response and any potential side effects is essential when using atropine.

Considerations for Drug Selection

Choosing the right medications for end-of-life care requires careful consideration of various factors. It is essential to take into account the individual patient’s preferences, needs, and goals of care. Additionally, healthcare providers must consider potential drug interactions and adverse effects when prescribing medications. Collaboration between healthcare providers, patients, and their families is vital to ensure that the selected drugs are appropriate for the patient’s specific situation and align with their values and wishes.

Administration Methods

There are several methods of medication administration in end-of-life care. The choice of administration route depends on factors such as the patient’s condition, the urgency of symptom relief, and their ability to take medications orally. Some common administration methods include oral administration (swallowing tablets or liquid medication), sublingual administration (placing medication under the tongue for absorption), transdermal administration (applying medication patches to the skin), intravenous administration (delivering medication directly into the bloodstream), and rectal administration (using suppositories).

Ethical Considerations in End-of-Life Medication Administration

When providing end-of-life care, ethical considerations surrounding medication administration come into play. Informed consent and shared decision-making are crucial, ensuring that patients and their families have a clear understanding of the benefits, risks, and expected outcomes of the medications being administered. Palliative sedation, a practice that aims to alleviate intractable suffering through sedation, while controversial, is sometimes used in end-of-life care. The principle of double effect, which addresses the unintended consequences of medication use, is also a factor to consider. Additionally, the legality and regulations surrounding end-of-life medication may vary depending on the country or state.


In end-of-life care, medication plays a significant role in providing comfort and managing symptoms for patients. Commonly prescribed drugs such as acetaminophen, haloperidol, lorazepam, morphine, prochlorperazine, and atropine are used to address pain, anxiety, restlessness, nausea, and respiratory issues. The selection and administration of medications require careful consideration of individual patient preferences, potential interactions, and ethical factors. By providing personalized and compassionate care, healthcare providers can enhance the quality of life for patients during this critical stage.


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