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Which hormone is responsible for happiness?

Happiness is an emotion that everyone wants to experience. But what exactly causes us to feel happy? Research shows that our hormones play a major role in regulating our moods and emotions. In particular, there are a few key hormones that are strongly associated with boosting happiness levels.


Dopamine is one of the main feel-good neurotransmitters in the brain. It plays a key role in motivation, pleasure, and reward-driven behaviors. When dopamine is released, it activates the reward centers in the brain, causing us to feel happier and more satisfied. Studies show that dopamine levels increase when we experience something pleasurable, like eating delicious food, having sex, or doing enjoyable hobbies. Drugs like cocaine also cause a flood of dopamine in the brain, which creates a temporary euphoric high.

In terms of biology, dopamine helps reinforce behaviors that are critical for our survival. When we do something rewarding, like eating or spending time with loved ones, dopamine is released to motivate us to repeat those activities. Over time, this associative learning helps wire our brains to pursue healthy, pleasurable behaviors. Dopamine deficiencies are linked to conditions like depression, addiction, and Parkinson’s disease.


Oxytocin is a powerful hormone that acts as a neurotransmitter in the brain. It plays a major role in social bonding, reproduction, childbirth, and feelings of love and trust. Oxytocin is sometimes called the “love hormone” or “cuddle chemical” because levels of oxytocin increase when people hug, kiss, or have sex. Women also have a large oxytocin surge during childbirth and breastfeeding, which helps bond mother and child.

In terms of emotion, oxytocin enhances feelings of contentment, calmness, and security when we connect with others. Studies show that oxytocin decreases anxiety, fear, and stress levels. It also increases feelings of empathy and generosity. Overall, oxytocin helps forge social connections and feelings of intimacy that bring joy and happiness.


Serotonin is perhaps the most well-known happiness hormone. It is a neurotransmitter that plays a key role in stabilizing mood, feelings of well-being, happiness, and sleep quality. Optimal serotonin levels are associated with emotional balance, relaxation, and reduced depression and anxiety.

When serotonin levels dip, it can negatively impact mood and lead to depression in some people. Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that work by increasing serotonin levels in the brain. This helps boost mood and alleviate depression. Serotonin deficiencies have also been linked to lower bone density and migraines.


Endorphins are neurotransmitters produced naturally by the central nervous system to cope with pain or stress. Like morphine, endorphins interact with opioid receptors in the brain to reduce pain perception and enhance feelings of pleasure. They are sometimes described as the body’s natural pain killer.

During activities like exercising, laughing, dancing, playing sports, or eating spicy foods, endorphins are released to trigger positive emotions. Studies show that higher endorphin levels are associated with fewer negative effects of stress, increased optimism and self-esteem, and lower rates of depression and anxiety. Endorphins give us a natural high and mind-body buzz.


DHEA, or dehydroepiandrosterone, is a pre-hormone produced by the adrenal glands. DHEA is converted into testosterone and estrogen within the body. DHEA levels decline naturally as we age. Research shows supplemental DHEA may improve mood, well-being, and sexuality in middle-aged and elderly populations with low DHEA levels.

However, study results are mixed overall regarding DHEA’s impact on happiness. Some studies found DHEA improved symptoms of depression, while others showed no significant effect. More research is needed on the exact effects of restoring DHEA levels on mood and emotion.

Summary of Main Happiness Hormones

Hormone Role
Dopamine Influences motivation, pleasure, and reward-driven behaviors
Oxytocin Promotes social bonding, childbirth/breastfeeding, love, and trust
Serotonin Stabilizes mood, sleep, and feelings of well-being
Endorphins Reduce pain perception and trigger positive emotions
DHEA May improve mood, well-being, and sexuality in those with low levels

Other Hormones that Affect Mood

In addition to the major hormones described above, here are some other hormones that can impact happiness and mood:


Estrogen is one of the main female sex hormones. Some women report mood swings, anxiety, and depression during low-estrogen phases of the menstrual cycle and after menopause. Estrogen may influence neurotransmitters like serotonin that affect mood.


Progesterone balances the effects of estrogen in women. Declining progesterone levels are linked to premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), which can cause mood swings, irritability, anxiety, and depression in some women.


Testosterone is the primary male sex hormone, though women also have small amounts. Low testosterone in men is associated with depression, fatigue, and low motivation. However, too much testosterone can also negatively impact mood.

Thyroid hormones

Thyroid hormones regulate metabolism. An overactive or underactive thyroid can cause mood disruptions like anxiety, depression, mood swings, and irritability.


Cortisol is released by the adrenal glands to help the body respond to stress. High cortisol levels from chronic stress can contribute to anxiety, depression, and other mental health issues.

Lifestyle Changes to Support Happiness Hormones

While we don’t have direct conscious control over our hormones, we can adopt habits and lifestyle changes to help optimize hormone levels in a way that supports better mood and happiness.

Here are some tips:

  • Exercise regularly – this stimulates endorphin and dopamine release.
  • Get enough high quality sleep – allows hormones to rebalance.
  • Reduce stress – curbs unhealthy cortisol spikes.
  • Eat a nutrient-rich diet – provides building blocks for hormones.
  • Try supplements like fish oil, vitamin D, and probiotics – may support hormone balance.
  • Practice self-care and relaxation techniques – lowers stress hormones.
  • Form meaningful social connections – boosts oxytocin.
  • Do activities you enjoy – releases dopamine.
  • Get sunlight exposure – helps serotonin production.

The Gut-Brain Connection

Emerging research shows that the gut microbiome also influences hormone levels and mood. The gut and brain are constantly communicating via the vagus nerve, the central nervous system, and metabolites released by gut bacteria.

When gut health is compromised, it can impair mood and lead to issues like anxiety, depression, and trouble managing stress. Supporting a healthy gut microbiome through diet, lifestyle, and probiotic supplements may help optimize hormone signaling involved in mood and happiness.


In summary, our complex neuro-hormonal systems have an enormous influence over our mental health and happiness levels. Key hormones like dopamine, oxytocin, serotonin, endorphins, and DHEA are most directly linked to boosting mood and feelings of well-being.

While we don’t have direct control over our hormones, adopting a healthy lifestyle can help nudge our bodies into a state of hormonal balance that optimizes mental health. Factors like nutrition, exercise, stress management, social connection, and gut health all contribute to harmony between the mind and body.

By supporting our natural hormone physiology, we can increase resilience, stabilize mood, and enhance our overall enjoyment of life.