Skip to Content

Why can’t we get rid of lice?

Lice have been a nuisance to humans for thousands of years. Despite modern medicine and hygiene practices, these tiny insects continue to find ways to infest our hair and cause frustration. Understanding why lice are so difficult to eradicate requires examining their biology, behavior, and ability to develop resistance.

What are lice?

There are three main types of lice that affect humans:

  • Head lice
  • Body lice
  • Pubic lice

Lice are wingless insects that survive by feeding on human blood. They have claw-like legs specialized for clinging onto hair shafts. Their bodies are flat which allows them to press close to the scalp to avoid detection. Lice are also prolific breeders, with females laying up to 10 eggs per day.

Head lice

Head lice are the most common type of lice infestation. They cling to hair on the head and feed on scalp blood. Head lice spread easily through close head-to-head contact. Sharing hats, helmets, hair accessories, pillows, and brushes with an infested person can also transmit head lice.

Body lice

Body lice live on clothing and bedding and only move to the skin to feed. Poor hygiene practices that allow wearing of dirty clothing propagates body lice infestations. Body lice spread diseases like epidemic typhus, trench fever, and relapsing fever.

Pubic lice

As the name suggests, pubic lice inhabit the pubic hair and other coarse hair on the body. They spread through sexual contact and sharing of bedding or towels of an infected person. Pubic lice do not transmit disease but can cause itching in the genital area.

Why is it so hard to get rid of lice?

There are several biological and behavioral adaptations that make lice difficult to eradicate:

Rapid reproduction

A single female louse can produce up to 10 eggs or nits per day. These nits firmly attach to hair shafts as they develop. Ideal temperature conditions allow lice to hatch in 7-10 days. Newly hatched nymphs reach adulthood in 7-12 days. This rapid reproduction rate allows lice populations to bounce back quickly after attempted removal.

Evasion tactics

Lice avoid detection in several ways:

  • They cling close to the scalp to avoid notice.
  • Their flattened bodies allow them to squeeze into narrow spaces like the area behind ears and around the nape of the neck.
  • Lice move quickly from strand to strand to evade combs or other removal attempts.

Resistance to treatments

Over time, lice can develop genetic mutations that make them resistant to pediculicides – the chemical agents designed to kill them. This has occurred with many popular lice treatment shampoos and rinses over the past several decades.

Ability to live away from a host

Head and body lice can only survive 1-2 days off a human host. But lice eggs can remain viable for up to 10 days on bedding, clothing and other surfaces. This allows them to reinfest someone after attempted removal.

Why can’t we develop a 100% effective treatment?

The ideal lice treatment would kill all active lice and unhatched eggs quickly and effectively in one application. However, developing such a “silver bullet” treatment has proven difficult for several reasons:

Short life cycles

The short 7-12 day lice life cycle means generations of resistance can develop in a matter of weeks. This makes it difficult for a new treatment to remain effective long-term.

Resistance mechanisms

There are several ways lice can genetically develop resistance:

  • Target site insensitivity – Mutations prevent the treatment chemical from binding to lice cells.
  • Increased excretion – Lice develop ways to excrete or break down the toxic chemical before it kills them.
  • Reduced penetration – Their outer shell develops resistance to chemical absorption.

Treatment challenges

Issues with current lice treatments include:

  • They require perfect application for up to 10 minutes to work.
  • Many treatments must be applied multiple times.
  • Some chemicals cannot be used on children, pregnant women, or people with allergies.
  • No “nit-only” treatments exist to kill eggs and prevent self-reinfestation.

Case Study: Permethrin resistance

Permethrin is one of the most widely used pediculicides. It was extremely effective when first introduced in the 1980s. But within 10 years, lice populations began showing significant permethrin resistance. A 2009 study tested permethrin-resistant lice specimens from several U.S. cities. It found the resistant lice had developed a genetic “knockdown resistance” mutation that prevented permethrin from binding to nerve cells. This rendered it ineffective.

Permethrin Resistance Survey

City Number of Lice Samples Tested % with Resistance
Atlanta 47 100%
Dallas 21 95%
Los Angeles 32 87%
New York 53 83%

This table shows the rapid development of permethrin resistance across major U.S. cities within 10 years. By 2009, the vast majority of lice samples tested were highly resistant.

The ongoing challenge

Eradicating lice is extremely challenging due to their biological adaptations and ability to quickly develop genetic resistance. Even as new treatments are developed, lice evolve ways to evade them. While proper hygiene practices help reduce infestations, lice are likely to remain an irritation humans have to live with into the foreseeable future.

Frequently Asked Questions

What is the most effective lice treatment today?

Pyrethrins and permethrin remain the most effective and safe over-the-counter lice treatments. But their effectiveness continues to be compromised by resistance. Prescription-only treatments like ivermectin lotion, malathion lotion, and benzyl alcohol lotion may be more effective in some areas but are also expensive.

How do you kill lice eggs?

Lice eggs or nits are extremely difficult to kill as most pediculicides only target live lice. Frequent fine-tooth combing helps physically remove nits but can be labor intensive. Some prescription treatments like Ovide lotion and Nix Ultra can disrupt the nits’ metabolism and prevent hatching.

What home remedies work for lice?

Home remedies like mayonnaise, olive oil, and hair blow drying can help smother live lice but will not kill unhatched eggs. Fine-tooth nit combing every 2-3 days for 2 weeks helps remove the nits before they hatch and reinfest the scalp.

How do you prevent lice?

Prevention measures include avoiding head-to-head contact, not sharing personal items like combs and hats, and regularly checking children’s scalps. However, lice exposure can still happen unexpectedly in schools, sports activities, or social gatherings.


Lice have pestered humans for millennia and show no signs of disappearing due to their remarkable survival abilities. Their rapid breeding, evasion tactics, and genetic resistance enables them to overcome our attempts to eradicate them. While we can take steps to reduce infestations through hygiene and prevention, lice are likely to remain an inconvenient aspect of human existence into the foreseeable future.