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What blood pressure meds cause depression?

High blood pressure, also known as hypertension, is a common health condition that affects millions of people worldwide. If left untreated, high blood pressure can lead to heart disease, stroke, and other serious medical complications. While there are many effective medications available to lower blood pressure, some of these drugs may cause side effects like depression in some patients.

Beta Blockers

Beta blockers are a class of drugs that block the effects of adrenaline in the body and slow down your heart rate. This reduces blood pressure by decreasing the force of blood pumped through your arteries. While beta blockers are very effective at lowering blood pressure, they have been associated with increased risk of depression and fatigue in some individuals.

Some common beta blockers that may cause depression include:

  • Atenolol (Tenormin)
  • Metoprolol (Lopressor, Toprol-XL)
  • Propranolol (Inderal)
  • Carvedilol (Coreg)
  • Bisoprolol (Zebeta)

The exact mechanism by which beta blockers may trigger depression is not fully understood. However, researchers believe it may be related to their effects on adrenaline and serotonin levels in the brain.

Calcium Channel Blockers

Calcium channel blockers, also known as calcium antagonists, are another class of blood pressure medications that may increase the risk of depression in some people. These drugs work by relaxing the muscles in the walls of your arteries, allowing the vessels to dilate and lowering blood pressure.

Some calcium channel blockers that have been linked to depressive symptoms include:

  • Amlodipine (Norvasc)
  • Diltiazem (Cardizem)
  • Verapamil (Calan, Isoptin)
  • Nifedipine (Procardia)

The potential mechanisms by which calcium channel blockers could contribute to depression are not fully clear. Some experts believe the drugs may disrupt calcium ion channels in the brain that are involved in regulating mood.

ACE Inhibitors

Angiotensin converting enzyme (ACE) inhibitors are used to treat high blood pressure by preventing formation of angiotensin II, a hormone that narrows blood vessels. This widening of the blood vessels results in lower blood pressure.

Some ACE inhibitors that may be linked with increased depressive symptoms include:

  • Captopril (Capoten)
  • Enalapril (Vasotec)
  • Lisinopril (Prinivil, Zestril)
  • Ramipril (Altace)

How ACE inhibitors may trigger depression is not fully understood. One hypothesis is that they may impact serotonin and norepinephrine activity in the brain, which are neurotransmitters involved in regulating mood.

Other Blood Pressure Medications

In addition to the drug classes discussed above, some other blood pressure medications have also been associated with increased risk of depression in some patients:

  • Clonidine – Central acting alpha-2 agonist that reduces nerve impulses to blood vessels.
  • Methyldopa – Centrally acting alpha-2 agonist that decreases nerve signals to the heart and blood vessels.
  • Reserpine – Depletes stores of catecholamines like norepinephrine in nerve endings.

The potential mechanisms linking these drugs to depressive symptoms are likely related to their effects on neurotransmitters like norepinephrine.

Risk Factors for Depression

It’s important to keep in mind that not everyone taking blood pressure medications will experience depression as a side effect. Some factors that may increase your risk include:

  • Personal or family history of depression
  • Being female – women are twice as likely to be affected than men
  • Age – older adults are at increased risk
  • Stressful life events
  • Chronic health conditions
  • Genetics – gene mutations may play a role
  • Imbalance in brain chemicals like serotonin or norepinephrine

If you have any of these risk factors, be sure to let your doctor know before starting a new blood pressure medication, as they may monitor you more closely for any changes in mood.

Signs and Symptoms

Some common signs and symptoms of depression that you may experience when taking blood pressure medication can include:

  • Persistent sadness, anxiousness, or “empty” feelings
  • Feelings of hopelessness, worthlessness, or helplessness
  • Irritability or restlessness
  • Loss of interest in hobbies and activities
  • Fatigue and decreased energy
  • Difficulty concentrating, remembering, or making decisions
  • Sleep disturbances like insomnia or sleeping too much
  • Changes in appetite and weight
  • Aches, pains, headaches, cramps, or digestive issues
  • Thoughts of death or suicide

Pay close attention to any unusual changes in your mood, energy, behavior, or thoughts that develop after starting a new blood pressure medication. The symptoms may range from mild to severe.

Treatment Options

If you experience depression or concerning mental health changes while taking blood pressure medication, speak to your doctor right away about treatment options. Some strategies may include:

  • Switching to an alternative blood pressure medication that may have less effects on mood.
  • Adding an antidepressant medication to help increase serotonin or norepinephrine activity in the brain.
  • Starting therapy or counseling to help manage depressive symptoms.
  • Lifestyle changes like exercise, stress management, and improved sleep habits.

In many cases, simple adjustments like changing the timing of when you take your medication can also help. Your doctor will work with you to find the most effective treatment approach with minimal side effects.


There are some proactive steps you can take to help prevent depressive side effects when starting blood pressure medication:

  • Choose medication classes less likely to cause depression when possible – like diuretics or ARBs.
  • Start medication at the lowest dose and titrate up slowly.
  • Take medication earlier in the day if it causes fatigue or insomnia.
  • Monitor mood and energy levels closely after starting new medication.
  • Have close follow up with your doctor and report any concerning symptoms early.
  • Reduce stress, stay active, keep social connections, and care for your mental health.


While many effective medications for lowering blood pressure exist, some drug classes like beta blockers, calcium channel blockers, and ACE inhibitors may increase the risk of depression in susceptible individuals. Being aware of your personal risk factors, carefully monitoring any mood changes, and collaborating closely with your health care provider can help minimize this side effect. There are also many treatment options available if you do experience depression symptoms related to your blood pressure medication.